Metalated nitriles: SNi′ cyclizations with a propargylic electrophile
نویسندگان
چکیده
منابع مشابه
Reaction of metalated nitriles with enones.
[reaction: see text] There have been a number of reports of the kinetic conjugate (1,4) addition of metalated arylacetonitriles to enones. Several proposals have been made to explain this behavior based on nucleophile structure or aggregation state or on the HSAB properties of the reactants. A reexamination of these studies showed that in each case the 1,4 adducts resulted from equilibration of...
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ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 2015
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2015.01.013